Stretching biomolecules

RNA & Protein folding

Molecular Motors

Single molecule force spectroscopy

Deciphering the energy landscape of biomolecules

Polymer Physics

Allostery

  1. "Efficient Functional Delivery of siRNA using Mesoporous Silica Nanoparticles with Ultra Large Pores" H.-K. Na, M.-H. Kim, K. Park, S.-R. Ryoo, K.E. Lee, H. Jeon, R. Ryoo, C. Hyeon, D.-H. Min, Small (2012) in press
  2. "Force-induced Unbinding Dynamics in a Multidimensional Free Energy Landscape" C. Hyeon Bull. Korean Chem. Soc. - K. J. Shin Festshrift (2012) vol. 33, 897-900 http://arxiv.org/abs/1201.2449
  3. "Chain Length Determines the Folding Rates of RNA" C. Hyeon & D. Thirumalai Biophys. J. (2012) vol. 102, L11-L13 .
  4. "A structural perspective on the dynamics of kinesin motors" C. Hyeon & J. N. Onuchic Biophys. J. (2011) vol. 101, 2749 , SI
  5. "Link between Allosteric Signal Transduction and Functional Dynamics in a Multisubunit Enzyme: S-Adenosylhomocysteine Hydrolase" Y. Lee, L.S. Jeong, S. Choi, & C. Hyeon J. Am. Chem. Soc.  (2011) vol. 133, 19807-19815  ,  SI , Movie  ,  .
  6. "Capturing the essence of folding and functions of biomolecules using Coarse-Grained Models" C. Hyeon & D. Thirumalai Nature Communications (2011) vol 2, 487
  7. "Compaction and tensile forces determine the accuracy of folding landscape parameters from single molecule pulling experiments" G. Morrison, C. Hyeon, M. Hinczewski & D. Thirumalai Phys. Rev. Lett. (2011) vol. 106, 138102
  8. "Theoretical Perspectives on Protein Folding" D. Thirumalai, E. P. O'Brien, G. Morrison & C. Hyeon Annu. Rev. Biophys. (2010) vol. 39, 159-183
  9. "Dynamic Ca2+-Dependent Stimulation of Vesicle Fusion by Membrane-Anchored Synaptotagmin 1" H. -K. Lee, Y. Yang, Z. Su, C. Hyeon, T. -S. Lee, H. -W. Lee, D. -H. Kweon, Y. -K. Shin & T. -Y. Yoon Science (2010) vol. 328, 760-763 , SOM
  10. "Urea destabilizes RNA by forming stacking interactions and multiple hydrogen bonds with nucleic acid bases" U. D. Priyakumar, C. Hyeon, D. Thirumalai & A. D. MacKerell Jr. J. Am. Chem. Soc. (Communication) (2009) vol.131, 17759-17761 , Supporting Info *** featured in C&EN news
  11. "Refolding dynamics of stretched biopolymers upon force-quench" C. Hyeon, G. Morrison, D. L. Pincus, & D. Thirumalai, Proc. Natl. Acad. Sci. (2009) vol. 106, 20288-20293 , Supporting Info
  12. "Metal Ion Dependence of Cooperative Collapse Transitions in RNA" S. Moghaddam, G. Caliskan, S. Chauhan, C. Hyeon, R. M. Briber, D. Thirumalai & S. A. Woodson, J.  Mol. Biol. (2009) vol. 393, 753-764
  13. "Kinesin's Backsteps under Mechanical Load" C. Hyeon, S. Klumpp & J. N. Onuchic, Phys. Chem. Chem. Phys. (2009) vol. 11, 4899-4910
  14. "Ligand-induced global transition in the catalytic domain of protein kinase A" C. Hyeon, P. A. Jennings, J. A. Adams & J. N. Onuchic, Proc. Natl. Acad. Sci. (2009) vol. 106, 3023-3028,  Supporting  info , Movie  .
  15. "Force dependent hopping rates of RNA hairpins can be estimated from accurate measurement of the folding landscapes" C. Hyeon, G. Morrison & D. Thirumalai, Proc. Natl. Acad. Sci. (2008) vol. 105, 9604-9609 ,  Supporting  info.
  16. "Effects of Trimethylamine N-Oxide (TMAO) and Crowding Agents on the stability of RNA hairpins" D. L. Pincus, C. Hyeon & D. Thirumalai, J. Am. Chem. Soc. (2008) vol. 130, 7364-7372 ,  Supporting  info.
  17. "Kinetics of loop formation in polymer chains" N. M. Toan, G. Morrison, C. Hyeon & D. Thirumalai, J. Phys. Chem. B (2008) vol. 112, 6094-6106 
  18. "Multiple probes are required to explore and control the rugged energy landscape of RNA hairpins" C. Hyeon & D. Thirumalai, J. Am. Chem. Soc. (Communication) (2008) vol. 130, 1538-1539  Supporting Info. 
  19. "Revealing the bifurcation in the unfolding pathways of GFP using single molecule experiments and simulations" M. Michkler, R. I. Dima, H. Dietz, C. Hyeon, D. Thirumalai & M. Rief Proc. Natl. Acad. Sci. (2007) vol. 104, 20268-20273 
  20. "Mechanical control of the directional stepping dynamics of the kinesin motor" C. Hyeon & J. N. Onuchic, Proc. Natl. Acad. Sci. (2007) vol. 104, 17382-17387 , Supporting Info. 
  21. "Stretching Homopolymers" G. Morrison, C. Hyeon, N. M. Toan, B. -Y. Ha & D. Thirumalai, Macromolecules (2007) vol. 40, 7343-7353 
  22. "Charge density of divalent metal cations determines RNA stability" E. Koculi, C. Hyeon, D. Thirumalai, & S. A. Woodson, J. Am. Chem. Soc. (2007) vol. 129, 2676-2682 
  23. "Measuring the energy landscape roughness and the transition state location of biomolecules using single molecule mechanical unfolding experiments" C. Hyeon & D. Thirumalai, J. Phys.:Condens. Matter (2007) vol. 19, 113101 
  24. "Internal strain regulates the nucleotide binding site of the kinesin leading head" C. Hyeon & J. N. Onuchic, Proc. Natl. Acad. Sci. (2007) vol. 104, 2175-2180 , Supporting Info. , SI Fig.6 , SI Fig.7 , SI Fig.8 , SI Fig.9 
  25. "Mechanical unfolding of RNA: From hairpins to structures with internal multiloops" C. Hyeon & D. Thirumalai, Biophys. J. (2007) vol. 92, 731-743 
  26. "Dynamics of allosteric transitions in GroEL" C. Hyeon, G.H. Lorimer & D. Thirumalai, Proc. Natl. Acad. Sci. (2006) vol. 103, 18939-18944 ,      Supporting materials 
  27. "Size, Shape, and flexibility of RNA structures" C. Hyeon, R. I. Dima, & D. Thirumalai, J. Chem. Phys. (2006) vol. 125, 194905 
  28. "Pathways and kinetic barriers in mechanical unfolding and refolding of RNA and proteins" C. Hyeon, R.I. Dima, & D. Thirumalai, Structure (2006) vol. 14, 1633-1645 
  29. "Forced-Unfolding and Force-Quench Refolding of RNA Hairpins" C. Hyeon & D. Thirumalai, Biophys. J. (2006) vol. 90, 3410-3427 
  30. "Kinetics of interior loop formation in semiflexible chains" C. Hyeon & D. Thirumalai, J. Chem. Phys. (2006) vol. 124, 104905 
  31. "Persistence Length Changes Dramatically as RNA Folds" G. Caliskan, C. Hyeon, U. Perez-Salas, B.M. Briber, S.A. Woodson, & D. Thirumalai, Phys. Rev. Lett. (2005) vol. 95, 268303 
  32. "RNA and Protein Folding: Common Themes and Variations" D. Thirumalai & C. Hyeon, Biochemistry (2005) vol. 44, 4957-4970 
  33. "Extracting Stacking Interaction Parameters for RNA from the Data Set of Native Structures" R.I. Dima, C. Hyeon, and D. Thirumalai, J. Mol. Biol. (2005) vol. 347, 53-69 
  34. "Mechanical unfolding of RNA hairpins" C. Hyeon & D. Thirumalai, Proc. Natl. Acad. Sci. (2005) vol. 102, 6789-6794  
  35. "Can energy landscape roughness of proteins and RNA be measured using mechanical unfolding experiments?" C. Hyeon & D. Thirumalai, Proc. Natl. Acad. Sci. (2003) vol. 100, 10249-10253 
  36. "One-pot Template Synthesis and Properties of a Molecular Bowl: Dodecaaza Macrotetracycle with mu(3)-Oxo and mu(3)-Hydroxo Tricopper(II) Cores" M. Paik Suh, M.Y. Han, J.H.Lee K.S.Min, & C. Hyeon. J. Am. Chem. Soc. (Communication) (1998) vol. 120, 3819-3820 
  37. "Effects of a quantum-mechanically driven two-state gating mode on the diffusion-influenced bimolecular reactions" Y. Jung, C. Hyeon, S. Shin, & S. Lee, J. Chem. Phys. (1997) vol. 107, 9864  

                   
                  

Book Chapter
  1. "Exploring the energy landscape of biopolymers using single-molecule force spectroscopy and molecular simulations" C. Hyeon in Chapter 5 in "Simulations in Nanobiotechnology" edited by K. Eom (2011) Taylor & Francis
  2. "Energy balance amd Dynamics of Kinesin Motors" C. Hyeon, & José N. Onuchic in Chapter 1 in "Proteins: Energy, Heat and Signal Flow" edited by D. M. Leitner and J. E. Straub (2009) CRC Press (Part of the book is scanned, available in google book. Follow this web link)
  3. D.L. Pincus, S.S. Cho, C. Hyeon, & D. Thirumalai, "Minimal Models for Protein and RNA: From Folding to Function", Chapter 6 in Progress in Molecular Biology and Translational Science edited by P. Michael Conn (2008) Academic Press, Vol. 84.
  4. "Theory of RNA Folding: From Hairpins to Ribozymes" D. Thirumalai & C. Hyeon, Chapter 2 in Non-Protein Coding RNAs edited by Nils G. Walter, Sarah A. Woodson, and Rober T. Batey (2008) Springer Series in Biophysics, Vol. 13 (Part of the book is scanned in google book. Follow this web link)
  5. "Coarse-Grained Structure-Based Simulations of Proteins and RNA" A. Schug, C. Hyeon, & J. N. Onuchic, Chapter 9 in Coarse-Graining of Condensed Phase and Biomolecular Systems edited by G. A. Voth (2008) CRC Press (Part of the book is scanned in google book. Follow this web link)

Essay

전산모사를 이용한 생체분자모터 동역학의 이해 (물리학과 첨단기술, May 2011, 27-31)
생물물리학의 방법론 (한국생물물리학회 Newsletter 제14권 1호 2009.05)
열적 요동과 생물물리학 (고등과학원 소식지, "과학의 지평" no.43, 2010)


Contact Information : Changbong Hyeon, Professor, School of Computational Sciences, Korea Institute for Advanced Study 130-722, Republic of Korea
+82-2-958-3810 (tel)

© 2010 KIAS Theoretical and Computational Biophysics Group