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Publications by category /
Publications
in reverse chronological order
Deciphering folding
landscapes of biomolecules, Single
molecule
spectroscopy
- "Deciphering
kinetic information from single molecule
FRET data that show slow transitions" S.
E. Kim, I. -B. Lee, C. Hyeon, S.-C. Hong
J. Phys. Chem. B. (2015) vol.
119, 6974–6978
- "Destabilization
of i-motif by submolar concentrations of
a monovalent cation" S. Kim, I.-B. Lee,
C. Hyeon, S.-C. Hong J. Phys. Chem.
B. (2014) vol. 118, 4753-4760.
- "Evidence
of disorder in biological molecules from
single molecule pulling experiments" C.
Hyeon, M. Hinczewski, D. Thirumalai Phys.
Rev. Lett. (2014) vol. 112, 138101 SI
- "Programmed
folding of DNA origami structures
through single-molecule force control"
W. Bae , K. Kim, D. Min, J.-K. Ryu, C.
Hyeon, T.-Y. Yoon Nat. Commun
(2014) vol. 5, 5654 SI
- "Real-Time
Observation of Multiple Protein-Complex
Formation with Single-Molecule FRET " W.
Bae, M.-G. Choi, C. Hyeon, Y.-K. Shin,
T.-Y. Yoon J. Am. Chem. Soc.
(Communication) (2013) vol. 135,
10254-10257 SI
- "Mechanical
unzipping and rezipping of a single
SNARE complex reveals hysteresis as a
force-generating mechanism" D. Min, K.
Kim, C. Hyeon, Y. H. Cho, Y.-K. Shin,
T.-Y. Yoon Nat. Commun. (2013) vol. 4,
1705 SI
- "Hidden
Complexity in the Isomerization Dynamics
of Holliday Junctions" C. Hyeon, J. Lee,
J. Yoon, S. Hohng, D. Thirumalai Nature
Chemistry (2012) vol. 4,
907-914 SI
- "Weak
temporal signals can synchronize and
accelerate the transition dynamics of
biopolymers under tension" W. K.
Kim, C. Hyeon & W. Sung Proc.
Natl. Acad. Sci. USA. (2012)
vol. 109, 14410-14415
- "Multiple
barriers in forced rupture of protein
complexes" C. Hyeon & D. Thirumalai
J.
Chem. Phys. (2012) vol. 137,
055103
- "Force-induced
Unbinding Dynamics in a Multidimensional
Free Energy Landscape" C. Hyeon Bull.
Korean Chem. Soc. - K. J. Shin
Festshrift (2012) vol. 33,
897-900 http://arxiv.org/abs/1201.2449
- "Compaction
and tensile forces determine the
accuracy of folding landscape parameters
from single molecule pulling
experiments" G. Morrison, C. Hyeon, M.
Hinczewski & D. Thirumalai Phys. Rev.
Lett. (2011) vol. 106, 138102
- (Book Chapter)
"Exploring the energy landscape of
biopolymers using single-molecule
force spectroscopy and molecular
simulations" C. Hyeon in
Chapter 5 in "Simulations in
Nanobiotechnology" edited by K.
Eom (2011) Taylor & Francis
- (Review)
"Theoretical Perspectives on Protein
Folding" D. Thirumalai, E. P. O'Brien,
G. Morrison & C. Hyeon Annu. Rev.
Biophys. (2010) vol. 39,
159-183
- "Refolding
dynamics of stretched biopolymers upon
force-quench" C. Hyeon, G. Morrison, D.
L. Pincus, & D. Thirumalai, Proc.
Natl. Acad. Sci. USA. (2009)
vol. 106, 20288-20293 ,
Supporting Info
- "Force
dependent hopping rates of RNA
hairpins can be estimated from
accurate measurement of the folding
landscapes" C. Hyeon, G. Morrison
& D. Thirumalai, Proc. Natl.
Acad. Sci. USA. (2008) vol.
105, 9604-9609 ,
Supporting info.
- "Revealing
the bifurcation in the unfolding
pathways of GFP using single molecule
experiments and simulations" M.
Michkler, R. I. Dima, H. Dietz, C.
Hyeon, D. Thirumalai & M. Rief Proc.
Natl. Acad. Sci. USA. (2007) vol.
104, 20268-20273
- (Review)
"Measuring the energy landscape
roughness and the transition state
location of biomolecules using single
molecule mechanical unfolding
experiments" C. Hyeon & D.
Thirumalai, J. Phys.:Condens.
Matter (2007) vol. 19,
113101
- "Pathways
and kinetic barriers in mechanical
unfolding and refolding of RNA and
proteins" C. Hyeon, R.I. Dima, & D.
Thirumalai, Structure (2006)
vol. 14, 1633-1645
- "Can
energy landscape roughness of proteins
and RNA be measured using mechanical
unfolding experiments?" C. Hyeon &
D. Thirumalai, Proc. Natl. Acad. Sci. USA (2003)
vol. 100, 10249-10253
Functional Dynamics of
Biomolecules (Enzymes & Molecular
Motors)
- "Communication
over the network of binary switches
regulates the activation of A2A
adenosine receptor" Y. Lee, S. Choi, C.
Hyeon PLoS Comp. Biol. (2015)
11(2): e1004044. , movie
M1 .
- "Mapping
the intramolecular signal transduction
of G-protein coupled receptors" Y. Lee,
S. Choi, & C. Hyeon Proteins:
Struct. Func. Bioinfo. (2014) vol.
82, 727-743 SI-I
,
SI-II
- "Spring-loaded
unraveling of a single SNARE complex by
NSF in one round of ATP turnover" J.-K.
Ryu, D. Min, S.-H. Rah, S. J. Kim, Y.
Park, H. Kim, C. Hyeon, H. M. Kim, R.
Jahn, T.-Y. Yoon Science (2015)
vol. 347, 1485-1489 , SI
- "The
origin of minus-end directionality and
mechanochemistry of Ncd motors" B. Jana,
C. Hyeon, J. N. Onuchic PLoS Comp.
Biol. (2012) 8(11): e1002783
- "Link
between Allosteric Signal Transduction
and Functional Dynamics in a
Multisubunit Enzyme: S-Adenosylhomocysteine
Hydrolase" Y. Lee, L.S. Jeong, S. Choi,
& C. Hyeon J. Am. Chem. Soc.
(2011) vol. 133, 19807-19815 ,
SI ,
Movie , .
- (Review)
"Capturing the essence of folding and
functions of biomolecules using
Coarse-Grained Models" C. Hyeon & D.
Thirumalai Nature Communications
(2011) vol 2, 487
- "A
structural perspective on the dynamics
of kinesin motors" C. Hyeon & J. N.
Onuchic Biophys. J. (2011)
vol. 101, 2749 , SI
- "Dynamic
Ca2+-Dependent Stimulation of
Vesicle Fusion by Membrane-Anchored
Synaptotagmin 1" H. -K. Lee, Y. Yang, Z.
Su, C. Hyeon, T. -S. Lee, H. -W. Lee, D.
-H. Kweon, Y. -K. Shin & T. -Y. Yoon
Science
(2010) vol. 328, 760-763 ,
SOM
- "Ligand-induced
global transition in the catalytic
domain of protein kinase A" C. Hyeon,
P. A. Jennings, J. A. Adams & J.
N. Onuchic, Proc. Natl. Acad.
Sci. USA. (2009) vol. 106,
3023-3028,
Supporting info ,
Movie .
- "Kinesin's
Backsteps under Mechanical Load" C.
Hyeon, S. Klumpp & J. N. Onuchic,
Phys. Chem. Chem. Phys. (2009)
vol. 11, 4899-4910
- (Book Chpater) "Energy
balance amd Dynamics of Kinesin
Motors" C. Hyeon, & José
N. Onuchic in Chapter 1 in "Proteins:
Energy, Heat and Signal Flow"
edited by D. M. Leitner and J. E. Straub
(2009) CRC Press (Part of the book is
scanned, available in google book. Follow
this web link)
- (Book
Chapter) D.L. Pincus, S.S. Cho, C.
Hyeon, & D. Thirumalai, "Minimal
Models for Proteins and RNA: From
Folding to Function", Chapter 6 in Progress
in Molecular Biology and
Translational Science edited by
P. Michael Conn (2008) Academic Press,
Vol. 84.
- (Book
Chapter) "Coarse-Grained
Structure-Based Simulations of
Proteins and RNA" A. Schug, C. Hyeon,
& J. N. Onuchic, Chapter 9 in
Coarse-Graining of Condensed Phase and
Biomolecular Systems edited by G. A.
Voth (2008) CRC Press (Part of the
book is scanned in google book.
Follow this web link)
- "Mechanical
control of the directional stepping
dynamics of the kinesin motor" C. Hyeon
& J. N. Onuchic, Proc. Natl.
Acad. Sci. USA. (2007) vol. 104,
17382-17387 ,
Supporting Info.
- "Internal
strain regulates the nucleotide binding
site of the kinesin leading head" C.
Hyeon & J. N. Onuchic, Proc.
Natl. Acad. Sci. USA (2007) vol.
104, 2175-2180 ,
Supporting Info. ,
SI Fig.6 ,
SI Fig.7 ,
SI Fig.8 ,
SI Fig.9
- "Dynamics
of allosteric transitions in GroEL" C.
Hyeon, G.H. Lorimer & D. Thirumalai,
Proc. Natl. Acad. Sci. USA
(2006) vol. 103, 18939-18944 , Supporting
materials
Polymer Physics
- "Unexpected
swelling of stiff DNA in a polydisperse
crowded environment" H. Kang, N. M.
Toan, C. Hyeon, D. Thirumalai J. Am.
Chem. Soc. (2015) vol. 137,
10970-10978
- "Effects
of macromolecular crowding on the
collapse of biopolymers" H. Kang, P. A.
Pincus, C. Hyeon, D. Thirumalai Phys.
Rev. Lett. (2015) vol. 114,
068303 , SI
- "Kinetics
of loop formation in polymer chains" N.
M. Toan, G. Morrison, C. Hyeon & D.
Thirumalai, J. Phys. Chem. B
(2008) vol. 112, 6094-6106
- "Stretching
Homopolymers" G. Morrison, C. Hyeon, N.
M. Toan, B. -Y. Ha & D. Thirumalai,
Macromolecules (2007) vol. 40,
7343-7353
- "Kinetics
of interior loop formation in
semiflexible chains" C. Hyeon & D.
Thirumalai, J. Chem. Phys.
(2006) vol. 124, 104905
RNA
- “Sequence-dependent
folding landscapes of adenine riboswitch
aptamers” J.-C. Lin, C. Hyeon, D.
Thirumalai Phys. Chem. Chem. Phys.
(2014) vol. 16, 6376
- "Development
and applications of Coarse Grained
models for RNA" C. Hyeon, N. A.
Denesyuk, D. Thirumalai Israel J.
Chem. (2014) vol. 54, 1358-1373
- "Dynamical
Transition and Heterogeneous Hydration
Dynamics in RNA" J. Yoon, J.-C. Lin, C.
Hyeon, D. Thirumalai J. Phys. Chem.
B. (2014) vol. 118, 7910-7919
- “Using
Simulations and kinetic network models
to reveal the dynamics and functions of
riboswitches” J.-C. Lin, J. Yoon, C.
Hyeon, D. Thirumalai, Methods in
Enzymology (2015) 553, 235-258
- "Generalized
Iterative Annealing Model for the action
of RNA chaperones" C. Hyeon & D.
Thirumalai J. Chem. Phys. (2013)
vol. 139, 121924
- "Urea-induced
denaturation of preQ1-riboswitch
" J. Yoon, D. Thirumalai, C. Hyeon J.
Am. Chem. Soc. (2013) vol. 135,
12112-12121 SI
Movie 1 , Movie
2 , Movie
3 , Movie
4 , Movie
5 , Movie 5
(detailed)
featured in JACS
spotlights
- (Perspective)
"RNA under Tension: Folding Landscapes,
Kinetic Partitioning Mechanism, and
Molecular Tensegrity" J.-C. Lin, C.
Hyeon, D. Thirumalai J. Phys. Chem.
Lett. (2012) vol. 3, 3616-3625
- "Chain
Length Determines the Folding Rates of
RNA" C. Hyeon & D. Thirumalai Biophys.
J. (2012) vol. 102, L11-L13 .
- "Urea
destabilizes RNA by forming stacking
interactions and multiple hydrogen bonds
with nucleic acid bases" U. D.
Priyakumar, C. Hyeon, D. Thirumalai
& A. D. MacKerell Jr. J. Am.
Chem. Soc. (Communication)
(2009) vol.131, 17759-17761 ,
Supporting Info
*** featured in C&EN news
- "Effects
of Trimethylamine N-Oxide (TMAO) and
Crowding Agents on the stability of
RNA hairpins" D. L. Pincus, C. Hyeon
& D. Thirumalai, J. Am. Chem.
Soc. (2008) vol. 130, 7364-7372 ,
Supporting info.
- "Size,
Shape, and flexibility of RNA
structures" C. Hyeon, R. I. Dima, &
D. Thirumalai, J. Chem. Phys.
(2006) vol. 125, 194905
- "Charge
density of divalent metal cations
determines RNA stability" E. Koculi, C.
Hyeon, D. Thirumalai, & S. A.
Woodson, J. Am. Chem. Soc.
(2007) vol. 129, 2676-2682
- "Multiple
probes are required to explore and
control the rugged energy landscape of
RNA hairpins" C. Hyeon & D.
Thirumalai, J. Am. Chem. Soc.
(Communication) (2008) vol. 130,
1538-1539 Supporting
Info.
- "Metal
Ion Dependence of Cooperative Collapse
Transitions in RNA" S. Moghaddam, G.
Caliskan, S. Chauhan, C. Hyeon, R. M.
Briber, D. Thirumalai & S. A.
Woodson, J. Mol. Biol. (2009)
vol. 393, 753-764
- (Book
Chapter) "Theory of RNA Folding:
From Hairpins to Ribozymes" D.
Thirumalai & C.
Hyeon,
Chapter 2 in Non-Protein
Coding RNAs edited
by Nils G. Walter, Sarah A. Woodson,
and Robert T. Batey (2008) Springer
Series in Biophysics, Vol. 13
(Part of the book is scanned in google
book. Follow
this web link)
- "Mechanical
unfolding of RNA: From hairpins to
structures with internal multiloops" C.
Hyeon & D. Thirumalai, Biophys.
J. (2007) vol. 92, 731-743
- "Forced-Unfolding
and Force-Quench Refolding of RNA
Hairpins" C. Hyeon & D. Thirumalai,
Biophys. J. (2006) vol. 90,
3410-3427
- "RNA
and Protein Folding: Common Themes and
Variations" D. Thirumalai & C.
Hyeon, Biochemistry (2005)
vol. 44, 4957-4970
- "Persistence
Length Changes Dramatically as RNA
Folds" G. Caliskan, C. Hyeon, U.
Perez-Salas, B.M. Briber, S.A.
Woodson, & D. Thirumalai, Phys. Rev.
Lett. (2005) vol. 95,
268303
- "Extracting
Stacking Interaction Parameters for RNA
from the Data Set of Native Structures"
R.I. Dima, C. Hyeon, and D. Thirumalai,
J.
Mol. Biol. (2005) vol. 347,
53-69
- "Mechanical
unfolding of RNA hairpins" C. Hyeon
& D. Thirumalai, Proc.
Natl. Acad. Sci. USA (2005)
vol. 102, 6789-6794
Miscellaneous
- "Real-time
single-molecule co-immunoprecipitation
analyses reveal cancer-specific Ras
signaling dynamics" H.-W. Lee, T. Kyung,
J. Yoo, T. Kim, C. Chung, J.Y. Ryu, H.
Lee, K. Park, S. Lee, W.D. Jones, D.-S.
Lim, C. Hyeon, W.D. Heo, T.-Y. Yoon Nature
Communications (2013) vol. 4, 1505
SI
- "Efficient
Functional Delivery of siRNA using
Mesoporous Silica Nanoparticles with
Ultralarge Pores" H.-K. Na, M.-H. Kim,
K. Park, S.-R. Ryoo, K.E. Lee, H. Jeon,
R. Ryoo, C. Hyeon, D.-H. Min, Small
(2012) vol. 8, 1752-1761 , SI
- "One-pot
Template Synthesis and Properties of a
Molecular Bowl: Dodecaaza
Macrotetracycle with mu(3)-Oxo and
mu(3)-Hydroxo Tricopper(II) Cores" M.
Paik Suh, M.Y. Han, J.H.Lee K.S.Min,
& C. Hyeon. J. Am.
Chem. Soc. (Communication)
(1998) vol. 120, 3819-3820
- "Effects
of a quantum-mechanically driven
two-state gating mode on the
diffusion-influenced bimolecular
reactions" Y. Jung, C. Hyeon, S. Shin,
& S. Lee, J. Chem. Phys. (1997)
vol. 107, 9864
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Contact
Information : Changbong Hyeon, Professor,
School of Computational Sciences, Korea
Institute for Advanced Study, Seoul 02455,
Republic of Korea
+82-2-958-3810
(tel)
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© 2010 KIAS Theoretical and
Computational Biophysics Group |
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