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Can energy landscape roughness of proteins and RNA be measured by using mechanical unfolding experiments? (PNAS '03) By considering temperature effects on the mechanical unfolding rates of
proteins and RNA, whose energy landscape is rugged, the question posed in the
title is answered in the affirmative. Adopting a theory by Zwanzig [Zwanzig,
R. (1988) Proc. Natl. Acad. Sci. USA 85, 2029-2030], we show that,
because of roughness characterized by an energy scale |